Research
The Laboratory of Computational Neuro-Oncology at the École Polytechnique Fédérale de Lausanne (EPFL) focuses on biomedical data science for children and young adults with brain tumours.
The laboratory is directed by Prof. Dr. Sebastian M Waszak and is affiliated with the Swiss Institute for Experimental Cancer Research (ISREC); the Centre for Molecular Medicine Norway (NCMM); the Pediatric Neuro-Oncology Consortium (PNOC); and the University of California, San Francisco (UCSF).
Our group focuses on the following research topics:
- To develop novel technologies for minimally-invasive and longitudinal molecular diagnostics in pediatric neuro-oncology (The Lancet Oncology 2018, Nature 2020)
- To study cancer genomes in precision medicine clinical trials (Clinical Cancer Research 2022, Cancer Discovery 2023, Journal of Clinical Oncology 2023)
- To study the genetic architecture and evolutionary history of brain tumours (Journal of Clinical Oncology 2019, Nature 2020, Acta Neuropathologica 2023)
We are hiring students and postdocs in clinical cancer genomics, digital pathology, statistical genetics, single-cell genomics, and long-read sequencing. Please email your CV, list of publications, and short motivation letter to sebastian.waszak[at]epfl.ch.
News
- Rational combination platform trial design for children and young adults with Diffuse Midline Glioma published in Neuro-Oncology
- PNOC001 trial results on everolimus for progressive/recurrent pLGGs and genomic biomarkers published in the Journal of Clinical Oncology
- Abstracts from the 28th SNO Meeting are published in Neuro-Oncology
- Novel long-term survival DMG subtype published in Acta Neuropathologica
- Pan-cancer atlas of somatic core and linker histone mutations published in npj Genomic Medicine