The new Sinergia consortium is dedicated to finding new and effective treatment strategies for diffuse midline glioma, a highly aggressive pediatric brain tumor.

The team involves principal investigators from the DMG/DIPG Center Zurich (Nazarian lab), the ETH Zurich (Yanik lab), the NCMM (Waszak lab), and project partners from the University Hospital Zurich, University of Zurich, University of California San Francisco, the Anticancer Fund, Elsevier, and the Children’s Brain Tumor Network.

Please read the press release from NCMM for more information about the consortium:

https://www.med.uio.no/ncmm/english/news-and-events/news/2020/international-consortium-receives-funding-from-the.html

Bonner ER, Waszak SM, Grotzer MA, Mueller S, Nazarian J. Mechanisms of imipridones in targeting mitochondrial metabolism in cancer cells. Neuro-Oncology (2020). doi:10.1093/neuonc/noaa283.

https://academic.oup.com/neuro-oncology/advance-article/doi/10.1093/neuonc/noaa283/6041425

We are happy to announce that Sebastian has joined the Editorial Board of Frontiers in Genetics as an Associate Editor. He will contribute to the strategic development and peer-review process of the new Specialty Section Cancer Genetics and Oncogenomics. More information about Frontiers’ and the new section will become soon available on https://www.frontiersin.org/journals/genetics.

Frida Moi, currently a Master’s student in Civil Engineering at the Norwegian University of Life Sciences (NMBU), will join our lab as a Research Assistant on Jan 1, 2021, and study the genomic and epigenomic landscape of H3K27M-mutant diffuse midline gliomas. Welcome to the lab!

Abed Rahman Kawakibi, Rohinton S Tarapore, Sharon Gardner, Chase Thomas, Rodrigo Cartaxo, Viveka Nand Yadav, Andrew Chi, Sylvia Kurz, Patrick Wen, Isabel Arrillaga-Romany, Tracy Batchelor, Nicholas Butowski, Ashley Sumrall, Nicole Shonka, Rebecca Harrison, John de Groot, Minesh Mehta, Yazmin Odia, Matthew Hall, Doured Daghistani, Timothy Cloughesy, Benjamin Ellingson, Yoshie Umemura, Hugh Garton, Andrea Franson, Patricia Robertson, Jonathan Schwartz, Evan Cantor, Zachary Miklja, Brendan Mullan, Amy Bruzek, Ruby Siada, Jessica Cummings, Alyssa Paul, Ian Wolfe, Li Jiang, Mariella Filbin, Pankaj Vats, Chandan Kumar-Sinha, Rajen Mody, Arul Chinnaiyan, Sriram Venneti, Guangrong Lu, Sabine Mueller, Daniel Martinez, Adam Resnick, Javad Nazarian, Sebastian Waszak, Joshua Allen, Carl Koschmann, CTNI-17. CLINICAL EFFICACY AND PREDICTIVE BIOMARKERS OF ONC201 IN H3 K27M-MUTANT DIFFUSE MIDLINE GLIOMA, Neuro-Oncology, Volume 22, Issue Supplement_2, November 2020, Pages ii45–ii46, https://doi.org/10.1093/neuonc/noaa215.184

Justyna Przystal, Sridevi Yadavilli, Christina Coleman Abadi, Viveka Nand Yadav, Sandra Laternser, Chiara Cianciolo Cosentino, Sebastian Waszak, Rodrigo Cartaxo, Matt Biery, Carrie Myers, Samantha Jayasekara, James Olson, Mariella Filbin, Nicholas Vitanza, Jason Cain, Carl Koschmann, Sabine Mueller, Javad Nazarian, DDRE-03. INTERNATIONAL PRECLINICAL DRUG DISCOVERY AND BIOMARKER PROGRAM INFORMING AN ADOPTIVE COMBINATORIAL TRIAL FOR DIFFUSE MIDLINE GLIOMAS, Neuro-Oncology, Volume 22, Issue Supplement_2, November 2020, Pages ii61–ii62, https://doi.org/10.1093/neuonc/noaa215.248

Analysis of chromatin accessibility of human T‐cell precursors revealed progressive chromatin condensation during maturation. Pediatric T‐ALLs resemble the most immature populations indicating that the epigenetic landscape of this type of leukemia is most similar to the earliest thymic precursors.

Erarslan-Uysal, Kunz, Rausch, Richter-Pechańska, et al. EMBO Mol Med (2020) doi: 10.15252/emmm.202012104.

Full paper: https://www.embopress.org/doi/full/10.15252/emmm.202012104